Address: 1 Beichen West Road, Chaoyang District, Beijing 100101, China Telephone: +86-10-64807185 Email: ghwang@ioz.ac.cn
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Education:
10/2015-5/2016 | Joint Ph.D. Infectious Diseases, Yale School of Medicine, Yale University, New Haven, United States. |
9/2011-9/2015 | Ph.D. Zoology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. |
9/2007-8/2011 | B.S. Plant Protection, College of Plant Protection, Henan Agricultural University, Zhengzhou, China. |
Research Experience:
Chinese Academy of Sciences, Beijing, China 2/2021 – Present
Principal Investigator in Institute of Zoology
University of California, San Diego, United States 10/2019 – 1/2021
Postdoctoral Fellow in Division of Biological Sciences, laboratory of Dr. Omar S. Akbari.
Project: Genetic basis of mosquito olfaction and behavior using genome engineering technologies.
Harvard University, Cambridge, United States 8/2016 – 10/2019
Postdoctoral Fellow in Rowland Institute, laboratory of Dr. Robert M. Brucker.
Project: Experimental testing microbe function: pesticides metabolism and speciation.
Yale University, New Haven, United States 9/2015 – 5/2016
Joint Ph.D. student in Infection of Disease, laboratory of Dr. Erol Fikrig.
Project: Exploring proteins that facilitate Plasmodium transmission from mosquito to mammal.
Chinese Academy of Sciences, Beijing, China 6/2011 - 9/2015
Ph.D. student in Institute of Zoology, laboratory of Dr. Da-Wei Huang.
Project: Functions of phage to endosymbiont and insect host.
Research Areas:
Evolutionary Biology; Entomology; Biological Engineering; Microbiology;
Publications (#co-first, *co-corresponding):
In English
14. Guan-Hong Wang*, Jie Du, Chenyi Chu, Grant L. Hughes, Jackson Champer* 2021. Symbionts and gene drive: two strategies to combat vector-borne disease. (Under revision at Trends in Genetics).
13. Wang, G.-H.*, B. M. Berdy, Brecia Douglas, Jing Wang, Robert M. Brucker*. 2021. Nutrient-microbiota-host interactions against pesticide and pathogen exposure. (Under review at Microbiome)
12. Wang, G.-H.*, and R. M. Brucker*. An optimized method for Nasonia germ-free rearing. 2022. Scientific Reports 12:219
11. Wang, G.-H.#, Stephanie Gamez#, Robyn Raban#, John Marshall, Luke Alphey, Ming Li, Jason Rasgon, Omar S. Akbari*. 2021. Combating mosquito-borne pathogens using genetic control technologies. Nature Communications 12, 4388. Citations: -
10. Wang G-H, Dittmer J, Douglas B, Huang L, Brucker RM*. 2021. Coadaptation between host genome and microbiome under long-term xenobiotic-induced selection. Science Advances 7, eabd4473. Citations: -
9. Wang, G.-H., B. M. Berdy, O. Velasquez, N. Jovanovic, S. Alkhalifa, K. P. C. Minbiole, and R. M. Brucker*. 2020. Changes in Microbiome Confer Multigenerational Host Resistance after Sub-toxic Pesticide Exposure. Cell Host & Microbe 27:213-224.e217. Citations: 24
Press Releases
By Ashley York, Nature Reviews Microbiology, February 17, 2020
· Passing on pesticide resistance
By Science Daily, Cell Press, February 4, 2020
· Wasps' gut microbes help them -- and their offspring -- survive pesticides
By Mary Todd Bergman, Harvard Correspondent, February 4, 2020
· Evaluating the hidden risks of herbicides
Beyond Pesticides, February 11, 2020
· Toxic Herbicide Atrazine Causes Wasp Gut Microbiome to Develop Pesticide Resistance Across Generations
By Kate Baggaley, Technology, February 5, 2020
· A healthy wasp microbiome can fend off pesticides
By Liji Thomas, Medical Science News, February 4, 2020
· Gut microbes in wasps help overcome pesticides
Popular Science, February 13, 2020
· Wasp microbes protect against pesticide
Industry News, February 13, 2020
· Gut microbes in wasps help overcome pesticides
8. Wang, G.-H., and R. M. Brucker*. 2019a. Genome sequence of Enterococcus faecalis NVIT04, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01156-01118. Citations: -
7. Wang, G.-H., and R. M. Brucker*. 2019b. Genome sequence of Providencia rettgeri NVIT03, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01157-01118. Citations: 5
6. Huan Li, Tongtong Li, Xiangzhen Li*, Guanhong Wang, Qiang Lin and Jiapeng Qu*. 2018. Gut microbiota in Tibetan herdsmen reflects the degree of urbanization. Frontiers in Microbiology 9:1745. Citations: 17
5. Guan-Hong Wang*, Bao-Fa Sun, Tuan-Lin Xiong, Yan-Kun Wang, Jin-Hua Xiao*, Da-Wei Huang*. 2016. Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes. Frontiers in Microbiology 7:1867. (*co-corresponding) Citations: 16
4. Guan-Hong Wang, Ling-Yi Jia, Jin-Hua Xiao*, Da-Wei Huang*. 2016. Discovery of a novel Wolbachia supergroup in cave spider species and the lateral transfer of phage WO among distant hosts. Infection, Genetics and Evolution 41 (2016) 1–7. Citations: 32
3. Guan-Hong Wang, Jin-Hua Xiao*, Li-Ming Niu, Guang-Chang Ma, and Da-Wei Huang*. 2014. Large proportion of genes in a cryptic WO prophage genome are actively transcribing in an insect species with sex-specific patterns: involvement in Wolbachia biology and reproductive manipulation? BMC Genomics 15:893. Citations: 14
2. G.-H. Wang, J.-H. Xiao*, T.-L. Xiong, Z. Li, R. W. Murphy, and D.-W. Huang*. 2013. High-Efficiency Thermal Asymmetric Interlaced PCR (hiTAIL-PCR) for determination of a highly degenerated prophage WO genome in a Wolbachia strain infecting a fig wasp species. Applied and Environmental Microbiology 79:7476-7481. Citations: 17
1. Xiao, Jin-Hua#; Yue, Zhen#; Jia, Ling-Yi#; Yang, Xin-Hua#; Niu, Li-Hua#; Wang, Zhuo#; Zhang, Peng#; Sun, Bao-Fa; He, Shun-Min; Li, Zi; Xiong, Tuan-Lin; Xin, Wen; Gu, Hai-Feng; Wang, Bo; Werren, John H.; Murphy, Robert W.; Wheeler, David; Niu, Li-Ming; Ma, Guang-Chang; Tang, Ting; Bian, Sheng-Nan; Wang, Ning-Xin; Yang, Chun-Yan; Wang, Nan; Fu, Yue-Guan; Li, Wen-Zhu; Yi, Soojin V.; Yang, Xing-Yu; Zhou, Qing; Lu, Chang-Xin; Xu, Chun-Yan; He, LiJuan; Yu, Li-Li; Chen, Ming; Zheng, Yuan; Wang, Shao-Wei; Zhao, Shuang; Li, Yan-Hong; Yu, Yang-Yang; Qian, Xiao-Ju; Cai, Yue; Bian, Lian-Le; Zhang, Shu; Wang, Jun-Yi; Yin, Ye; Xiao, Hui; Wang, Guan-Hong; Yu, Hui; Wu, Wen-Shan; Cook, James M.*; Wang, Jun*; Huang, Da-Wei*. 2013. Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology 14:R141. Citations: 81
In Chinese
2. Na Zhang, Man Zhao, Guan-Hong Wang*. 2022. Research progress on microorganism against pest and disease. Journal of Plant Protection 49(1):220-230.
1. Wei-Hua Li1, He Jiang1, Guan-Hong Wang1*. 2022. The progress in prevention and control of mosquito based on microorganism and gene editing. Journal of Plant Protection 49(1)：231-239.
Patent
1. Robert M. Brucker and Guan-Hong Wang. 2019. “Bacterial Probiotic to Detoxify Herbicides and Insecticides” (U.S. Patent No.: US 2019/0321417 A1). Equal inventorship. Citations: 1
Honors & Awards:
2018 | ASM Microbe Travel Award ($500), American Society for Microbiology |
2016 | Excellent Students Awards, University of Chinese Academy of Sciences |
2015 | Scholarship of Joint Ph.D. Training Program in Yale University ($12000) |
2015 | Excellent Students Awards, University of Chinese Academy of Sciences |
2014 | National Scholarship for Graduate Students ($5000) |
2014 | The National Virology Graduate Forum Awards ($200), Wuhan Institute of Virology, University of Chinese Academy of Sciences |
2014 | Excellent Students Awards, University of Chinese Academy of Sciences |
2014 | Youth Science and Technology Outstanding Paper, Beijing Entomological Society |
2013 | Application Skills Certificate of Scientific Graphing, International Association of Scientific Visualization |
2011 | Pacesetter College Students, Henan Agricultural University |
2010 | Excellent Students Awards, College of Plant Protection |
2010 | Prize of Business Plan Competition (Host), College of Plant Protection |
2009 | National Scholarship for Undergraduate Students ($1000) |
2009 | Excellent Students Awards, Henan Agricultural University |
2009 | Prize of Business Plan Competition (Host), College of Plant Protection |
2009 | Excellent Individual in Social Practice, College of Plant Protection |
2008 | National Scholarship for Undergraduate Students ($1000) |
Selected Presentations:
Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. University of Pennsylvania, Philadelphia, United States (Invited talk, full travel support).
Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. University of Chicago, Chicago, United States (Invited talk, full travel support).
Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. Carnegie Institution for Science, Maryland, United States (Invited talk, full travel support).
Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. University of Georgia, Athens, United States (Invited talk, full travel support).
Guan-Hong Wang, Robert M. Brucker 2019. Long-term experimental test microbiota can be a selection unit to host genotype. Ecological and Evolutionary Genomics Conference, Manchester, United States (Poster).
Guan-Hong Wang, Robert M. Brucker 2019. Long-term experimental test microbiota can be a selection unit to host genotype. Annual MIT-Harvard Microbiome Symposium, Manchester, United States (Invited poster).
Guan-Hong Wang, Robert M. Brucker 2018. Long-term exposure to pesticides changes function of microbiome, accelerating selection on host populations. American Society for Microbiology Conference, Atlanta, United States (Poster).
Guan-Hong Wang, Robert M. Brucker 2017. Long-term exposure to pesticides changes function of microbiome, accelerating selection on host populations. Harvard FAS Postdoc Research Symposium, Boston, United States (Poster).
Guan-Hong Wang, Robert M. Brucker 2017. Long-term exposure to pesticides changes function of microbiome, accelerating selection on host populations. Multi-omics for Microbiomes – EMSL Integration Conference, Pasco, United States (Poster).
Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2016. Phage function in symbiont and insect host. Harvard University, Boston, United States (Invited talk, full travel support).
Guan-Hong Wang, Tyler Schleicher, Jing Yang, Erol Fikrig 2016. A mosquito protein facilitates Plasmodium sporozoite survival in the vertebrate host. Yale School of Public Health, New Haven, United States (Invited talk, full travel support).
Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2014. Sex-specific transcription of large proportion of genes in the only cryptic WO prophage genome in a fig wasp species. 8th International Wolbachia Conference, Innsbruck, Austria (Talk).
Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2014. Bacteriophage, an important genetic vector player in the intracellular arena. The 3rd Session of the National Virology Graduate Forum, Wuhan, China (Talk).
Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2014. Role of phage WO to Wolbachia, and even insect host. Graduate Forum, Beijing, China (Poster).
Peer Reviewer:
BMC Ecology and Evolution, Development Genes and Evolution, Microbial Ecology, Insect Science, Insects,Frontiers in Microbiology, Frontiers in Genetics, Pollutants, Journal of Animal Ecology, PLOS ONE, JoVE,
Editorial Board:
Frontiers in Microbiology (2022- ), iMeta (2021- ), Acta Microbiologica Sinica (2021- ), Journal of Plant Protection (2021- ),
Mentorship:
As of Januray 2022, the wanglab.com.cn consists of: One Laboratory Manager (Jiang He) ---- One Assistant Professor (Wei-Hua Li, Ph.D.) ---- Two Postdoctoral Scholar (Yan-Jun Liu, Ph.D.; Qiqi Wang, Ph.D.) ----Three Graduate Students (Rong-Er Zheng B.S.; Zhu-Zheng Yu B.S.; Jia-Hui Wu B.S.).
For an updated list of active lab members (http://www.wanglab.com.cn/About.aspx?ClassID=29).
In addition to the active members, we have ~5 alumni consisting of former Postdocs, Students,
visiting scientists, lab techs etc.
Membership:
American Society for Microbiology (2018-2019)
Beijing Pesticide Society (2021-)
THE ENTOMOLOGICAL SOCIETY OF CHINA (2021-)
Beijing Entomological Society (2021-)